Differin Gel | Cream 0.1 % 15g


Differin Gel / Cream is used for the cutaneous treatment of mild to moderate acne where comedones, papules and pustules predominate. Acne of the face, chest or back is appropriate for treatment.

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Epiduo Gel is used for the treatment of acne.

  • The active substance in Differin is adapalene, which has an anti-inflammatory effect reducing soreness and irritation.
  • It is used on the face, chest or back for acne, where the skin has lots of blackheads, spots and pimples.
  • Differin is only absorbed into the body in very small amounts and has little effect, except on the surface of the skin.

Epiduo Gel contains:

Adapalene 1 mg (0.1%)

Adapalene is a chemically stable, naphthoic acid derivative with retinoid-like activity. Biochemical and pharmacological profile studies have proven that adapaleneacts in the pathology of Acne vulgaris: it is a potent modulator of cellular differentiation and keratinisation and it has anti-inflammatory properties. Mechanistically, adapalenebinds to specific retinoic acid nuclear receptors. Current evidence suggests that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Adapalene inhibits the chemotactic (directional) and chemokinetic (random) responses of human polymorphonuclear leucocytes in in vitro assay models; it also inhibits the metabolism of arachidonic acid to inflammatory mediators. In vitro studies have shown inhibition of the AP-1 factors and the inhibition of the expression of toll like receptors 2. This profile suggests that the cell mediated inflammatory component of acne is reduced by adapalene.


Directions to apply

Differin Gel / Cream should be applied to the acne affected areas once a day before retiring and after washing. A thin film of gel should be applied, with the fingertips, avoiding the eyes and lips.

With patients for whom it is necessary to reduce the frequency of application or to temporarily discontinue treatment, frequency of application may be restored or therapy resumed once it is judged that the patient can again tolerate the treatment.

If patients use cosmetics, these should be non-comedogenic and non-astringent.

Paediatric population: The safety and effectiveness of Differin Gel have not been studied in children below 12 years of age. Differin gel should not be used in patients with severe acne.


Shelf life: 3 years

For more info, please visit https://www.medicines.org.uk/emc/product/921/smpc


Other items containing Adapalene:

Epiduo Gel 15g

Additional information


Cream, Gel


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